Article
Key developmental transitions in human germinal center B cells are revealed by differential CD45RB expression.
Blood - 23 Apr 2009
Jackson Stephen M, Harp Natessa, Patel Darshna, Wulf Jordan, Spaeth Erich D, Dike Uzoamaka K, James Judith A, Capra J Donald
Abstract excerpt
We previously reported that RO(+) expression correlated with increased mutation, activation, and selection among human germinal center (GC) B cells. Here, we subdivided human tonsillar B cells, including IgD(-)CD38(+) GC B cells, into different fractions based on RB expression. Although each subset contained RB(+) cells, when used as an intrasubset marker, differential RB expression effectively discriminated...
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