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Article

Structure of the mechanically activated ion channel Piezo1.

Nature - 22 Feb 2018

Saotome Kei, Murthy Swetha E, Kefauver Jennifer M, Whitwam Tess, Patapoutian Ardem, Ward Andrew B

Abstract excerpt

Piezo1 and Piezo2 are mechanically activated ion channels that mediate touch perception, proprioception and vascular development. Piezo proteins are distinct from other ion channels and their structure remains poorly defined, which impedes detailed study of their gating and ion permeation properties. Here we report a high-resolution cryo-electron microscopy structure of the mouse Piezo1 trimer. The...

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Identifiers

PMID: 29261642
DOI: 10.1038/nature25453
PMCID: PMC6010196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure of the mechanically activated ion channel Piezo1.PMID 29261642Read ↗

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Levering Mechanically Activated Piezo Channels for Potential Pharmacological InterventionSemantic proximity Read ↗

Structure, kinetic properties and biological function of mechanosensitive Piezo channelsSemantic proximity Read ↗

A disease mutation reveals a non-swapped pore and rewired gating cycle of the mechanically activated PIEZO1 channelSemantic proximity Read ↗

MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels.Semantic proximity Read ↗

The structure of a conserved piezo channel domain reveals a topologically distinct β sandwich fold.Semantic proximity Read ↗

Molecular principles of Piezo1 activation by increased membrane tensionSemantic proximity Read ↗

A Propeller with a Flexible Twist: The Roles of Intrinsically Disordered Regions in PIEZO Gating and PIEZO-Associated ChannelopathiesSemantic proximity Read ↗

Structural Analysis of Piezo1 Ion Channel Reveals the Relationship between Amino Acid Sequence Mutations and Human DiseasesSemantic proximity Read ↗

Mechanosensing by Piezo1 and its implications in the kidneySemantic proximity Read ↗

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