Article
MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels.
Science (New York, N.Y.) - 18 Aug 2023
Zhou Zijing, Ma Xiaonuo, Lin Yiechang, Cheng Delfine, Bavi Navid, Secker Genevieve A, Li Jinyuan Vero, Janbandhu Vaibhao, Sutton Drew L, Scott Hamish S, Yao Mingxi, Harvey Richard P, Harvey Natasha L, Corry Ben, Zhang Yixiao, Cox Charles D
Abstract excerpt
Piezo channels are critical cellular sensors of mechanical forces. Despite their large size, ubiquitous expression, and irreplaceable roles in an ever-growing list of physiological processes, few Piezo channel-binding proteins have emerged. In this work, we found that MyoD (myoblast determination)-family inhibitor proteins (MDFIC and MDFI) are PIEZO1/2 interacting partners. These transcriptional regulators bind...
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