Article

A disease mutation reveals a non-swapped pore and rewired gating cycle of the mechanically activated PIEZO1 channel

2025-11-17

Abstract excerpt

PIEZO1 is a versatile mechanotranduction channel critical for diverse cellular and physiological processes 1–3 . Gain-of-function mutations, such as R2482H, which slow channel inactivation, are linked to dehydrated hereditary stomatocytosis (DHS) and iron overload 4–7 . PIEZO1 forms a gigantic bowl-shaped trimer comprising flattenable peripheral blades and a central pore module with a switchable cap 8–12 . Howe...

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Literature Corpus work: c098ab54-7963-5cc3-94d6-7d683731b516
DOI: 10.1101/2025.11.17.688653

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