Article
Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).
Atherosclerosis - 1 Feb 2018
McCarthy Nina S, Vangjeli Ciara, Surendran Praveen, Treumann Achim, Rooney Cathy, Ho Emily, Sever Peter, Thom Simon, Hughes Alun D, Munroe Patricia B, Howard Philip, Johnson Toby, Caulfield Mark, Shields Denis C, O'Brien Eoin, Fitzgerald Desmond J, Stanton Alice V
Abstract excerpt
BACKGROUND AND AIMS: Elevated urinary 11-dehydro thromboxane B2 (TxB2), a measure of thromboxane A2 formation in vivo, predicts future atherothrombotic events. To further understand this relationship, the genetic determinants of 11-dehydro TxB2 and their associations with cardiovascular morbidity were investigated in this study. METHODS: Genome-wide and targeted genetic association studies of urinary 11-dehydro...
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