Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Five Dimensions of Parkinson's Disease Genetic Risk.

Journal of Parkinson's disease - 1 Jan 2018

Coetzee Gerhard A, Pierce Steven

Abstract excerpt

Genome-wide association studies of Parkinson's disease have revealed polymorphic variants associated with closely mapped genes of interest. We propose here that those genes may only represent the tip of an iceberg of regulatory effects and do not necessary reflect disease relevance. To usefully interpret a risk locus, one needs to consider 5 dimensions of information, which represent the three-dimensional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Enhancer Elements, Genetic
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Parkinson Disease

Share to Promoter Regions, Genetic

Share to Quantitative Trait Loci

Share to Risk Factors

Share to Time Factors

Source

Identifiers

PMID: 29254107
DOI: 10.3233/JPD-171256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Five Dimensions of Parkinson's Disease Genetic Risk.PMID 29254107Read ↗

Genetic Risk Profiling in Parkinson's Disease and Utilizing Genetics to Gain Insight into Disease-Related Biological Pathways.Semantic proximity Read ↗

Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s DiseaseSemantic proximity Read ↗

Structural variation in Parkinson's disease : focusing on the role of transposable elements in disease predisposition and pathogenesisSemantic proximity Read ↗

Parkinson's disease genetic risk in a midbrain neuronal cell line.Semantic proximity Read ↗

Enrichment of risk SNPs in regulatory regions implicate diverse tissues in Parkinson's disease etiology.Semantic proximity Read ↗

Interaction-based feature selection algorithm outperforms polygenic risk score in predicting Parkinson’s Disease statusSemantic proximity Read ↗

Establishing gene regulatory networks from Parkinson's disease risk loci.Semantic proximity Read ↗

Effect Modification between Genes and Environment and Parkinson's Disease RiskSemantic proximity Read ↗

Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease.Semantic proximity Read ↗

Evaluation Of The <i>Rims2</i> Locus As A Risk Locus For Parkinson’s Disease DementiaSemantic proximity Read ↗

A cumulative genetic risk score predicts progression in Parkinson's disease.Semantic proximity Read ↗

Universal latent axes capturing Parkinson’s patient deep phenotypic variation reveals patients with a high genetic risk for Alzheimer’s disease are more likely to develop a more aggressive form of Parkinson’sSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.