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Article

Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination.

PloS one - 1 Jan 2017

Chen Yongfeng, Zhen Wei, Guo Tony, Zhao Yonggang, Liu Ailian, Rubio Justin P, Krull David, Richardson Jill C, Lu Hongtao, Wang Ryan

Abstract excerpt

BACKGROUND: Agents promoting oligodendrocyte precursor cell differentiation have the potential to restore halted and/or delayed remyelination in patients with multiple sclerosis. However, few therapeutic targets have been identified. The objective of this study was to identify novel targets for promotion of remyelination and characterize their activity in vitro and in vivo. METHODS: A high-content screening assay...

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Source

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Identifiers

PMID: 29253893
DOI: 10.1371/journal.pone.0189380
PMCID: PMC5734789

Genes

HRH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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