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High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel Targets

2022-01-20

Abstract excerpt

<h4>ABSTRACT</h4> Promoting myelination capacity of endogenous oligodendrocyte precursor cells (OPCs) is a promising therapeutic approach for central nervous system demyelinating disorders such as Multiple Sclerosis (MS). To aid in the discovery of myelination promoting compounds, we generated an advanced, genome engineered, human pluripotent stem cell (hPSC) line that consist of three reporters (identification-a...

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Literature Corpus work
03c1cf99-4b77-5bce-afdc-717827687134
DOI
10.1101/2022.01.18.476755
Open publication

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High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel TargetsDOI 10.1101/2022.01.18.476755
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