Article
Histamine H(3) receptor integrates peripheral inflammatory signals in the neurogenic control of immune responses and autoimmune disease susceptibility.
PloS one - 1 Jan 2013
Krementsov Dimitry N, Wall Emma H, Martin Rebecca A, Subramanian Meenakumari, Noubade Rajkumar, Del Rio Roxana, Mawe Gary M, Bond Jeffrey P, Poynter Matthew E, Blankenhorn Elizabeth P, Teuscher Cory
Abstract excerpt
Histamine H(3) receptor (Hrh3/H(3)R) is primarily expressed by neurons in the central nervous system (CNS) where it functions as a presynaptic inhibitory autoreceptor and heteroreceptor. Previously, we identified an H(3)R-mediated central component in susceptibility to experimental allergic encephalomyelitis (EAE), the principal autoimmune model of multiple sclerosis (MS), related to neurogenic control of blood...
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