Article
Specific T Cell Responses against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface.
Proteomics - 1 Jun 2018
Bijen Helena M, Hassan Chopie, Kester Michel G D, Janssen George M C, Hombrink Pleun, de Ru Arnoud H, Drijfhout Jan Wouter, Meiring Hugo D, de Jong Ad P, Falkenburg J H Frederik, Jimenez Connie R, Heemskerk Mirjam H M, van Veelen Peter A
Abstract excerpt
Allogeneic stem cell transplantation has emerged as immunotherapy in the treatment of a variety of hematological malignancies. Its efficacy depends on induction of graft versus leukemia by donor lymphocytes. Both graft versus leukemia and graft versus host disease are induced by T cells reactive against polymorphic peptides, called minor histocompatibility antigens (MiHA), which differ between patient and donor...
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