Article
The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens.
Investigative ophthalmology & visual science - 1 Jul 2010
Wiley Luke A, Dattilo Lisa K, Kang Kai B, Giovannini Marco, Beebe David C
Abstract excerpt
PURPOSE. Neurofibromatosis type 2 (NF2) is an autosomal-dominant CNS tumor syndrome that affects 1:25,000 children and young adults. More than 50% of NF2 patients also develop posterior subcapsular cataracts (PSCs). The authors deleted Nf2 from the lens to determine its role in fiber cell differe...
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