Article

Generation of a zebrafish neurofibromatosis model via inducible knockout of <i>nf2</i>

2024-04-27

Abstract excerpt

<h4>Summary</h4> Neurofibromatosis Type 2 (NF-2) is a dominantly inherited genetic disorder that results from mutations in the tumor suppressor gene, neurofibromin 2 (NF2) gene. Here, we report the generation of a conditional zebrafish model of neurofibromatosis established by an inducible genetic knockout of nf2a/b , the zebrafish homolog of human NF2. Analysis of nf2a and nf2b expression reveals ubiquitous e...

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Literature Corpus work: 3f198e0e-3b09-5340-8a65-eaae3dbd1346
DOI: 10.1101/2024.04.23.590787

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