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Article

The molecular biology of NF2/Merlin on tumorigenesis and development.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 15 Jul 2024

Vlashi Rexhina, Sun Fuju, Zheng Chenggong, Zhang Xingen, Liu Jie, Chen Guiqian

Abstract excerpt

The neurofibromatosis type 2 (NF2) gene, known for encoding the tumor suppressor protein Merlin, is central to the study of tumorigenesis and associated cellular processes. This review comprehensively examines the multifaceted role of NF2/Merlin, detailing its structural characteristics, functional diversity, and involvement in various signaling pathways such as Wnt/β-catenin, Hippo, TGF-β, RTKs, mTOR, Notch, and...

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Source

Identifiers

PMID: 38967126
DOI: 10.1096/fj.202400019RR

Genes

NF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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