Article

<i>Myelin regulatory factor</i> ( <i>Myrf</i> ) is a critical early regulator of retinal pigment epithelial development

2024-04-29

Abstract excerpt

<h4>ABSTRACT</h4> Myelin regulatory factor (Myrf) is a critical transcription factor in early retinal and retinal pigment epithelial development, and human variants in MYRF are a cause for nanophthalmos. Single cell RNA sequencing (scRNAseq) was performed on Myrf conditional knockout mice ( Rx>Cre Myrf fl/fl ) at 3 developmental timepoints. Myrf was expressed specifically in the RPE, and expression was abrog...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41c6487e-f88e-5342-8574-94cf95f65bb9
DOI: 10.1101/2024.04.26.591281

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Myelin regulatory factor</i> ( <i>Myrf</i> ) is a critical early regulator of retinal pigment epithelial developmentDOI 10.1101/2024.04.26.591281Read

Splicing variants in MYRF cause partial loss of function in the retinal pigment epitheliumSemantic proximity Read

Variants in myelin regulatory factor (MYRF) cause autosomal dominant and syndromic nanophthalmos in humans and retinal degeneration in miceSemantic proximity Read

Multi-omic analysis of photoreceptor alterations during early-onset retinal degeneration in <i> Mfrp <sup>-/-</sup> </i> miceSemantic proximity Read

The Microphthalmia-Associated Transcription Factor (MITF) and Its Role in the Structure and Function of the Eye.Semantic proximity Read

Truncation mutations in MYRF underlie primary angle closure glaucoma.Semantic proximity Read

Specialization of the photoreceptor transcriptome by <i>Srrm3</i> -dependent microexons is required for outer segment maintenance and visionSemantic proximity Read

Microphthalmia-associated transcription factor (MITF): multiplicity in structure, function, and regulation.Semantic proximity Read

MITF: a stream flowing for pigment cells.Semantic proximity Read

Zfp503/Nlz2 is Required for RPE Differentiation and Optic Fissure ClosureSemantic proximity Read

<i>Arhgef18</i> is a component of the outer limiting membrane required for retinal homeostasisSemantic proximity Read

SMIM36, a novel and conserved microprotein, is involved in retinal lamination in zebrafishSemantic proximity Read

Integrative Single‐Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental DynamicsSemantic proximity Read