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Article

Protein phosphatase 5 is a negative regulator of separase function during cortical granule exocytosis in C. elegans.

Journal of cell science - 1 Sept 2011

Richie Christopher T, Bembenek Joshua N, Chestnut Barry, Furuta Tokiko, Schumacher Jill M, Wallenfang Matthew, Golden Andy

Abstract excerpt

Mutations in the Caenorhabditis elegans separase gene, sep-1, are embryonic lethal. Newly fertilized mutant embryos have defects in polar body extrusion, fail to undergo cortical granule exocytosis, and subsequently fail to complete cytokinesis. Chromosome nondisjunction during the meiotic divisions is readily apparent after depletion of sep-1 by RNAi treatment, but much less so in hypomorphic mutant embryos. To...

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Identifiers

PMID: 21878498
DOI: 10.1242/jcs.073379
PMCID: PMC3166036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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