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Article

A deep sequencing approach to estimate Plasmodium falciparum complexity of infection (COI) and explore apical membrane antigen 1 diversity.

Malaria journal - 16 Dec 2017

Miller Robin H, Hathaway Nicholas J, Kharabora Oksana, Mwandagalirwa Kashamuka, Tshefu Antoinette, Meshnick Steven R, Taylor Steve M, Juliano Jonathan J, Stewart V Ann, Bailey Jeffrey A

Abstract excerpt

BACKGROUND: Humans living in regions with high falciparum malaria transmission intensity harbour multi-strain infections comprised of several genetically distinct malaria haplotypes. The number of distinct malaria parasite haplotypes identified from an infected human host at a given time is referred to as the complexity of infection (COI). In this study, an amplicon-based deep sequencing method targeting the...

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Identifiers

PMID: 29246158
DOI: 10.1186/s12936-017-2137-9
PMCID: PMC5732508

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