Article
Multiplicity and molecular epidemiology of Plasmodium vivax and Plasmodium falciparum infections in East Africa.
Malaria journal - 2 May 2018
Zhong Daibin, Lo Eugenia, Wang Xiaoming, Yewhalaw Delenasaw, Zhou Guofa, Atieli Harrysone E, Githeko Andrew, Hemming-Schroeder Elizabeth, Lee Ming-Chieh, Afrane Yaw, Yan Guiyun
Abstract excerpt
BACKGROUND: Parasite genetic diversity and multiplicity of infection (MOI) affect clinical outcomes, response to drug treatment and naturally-acquired or vaccine-induced immunity. Traditional methods often underestimate the frequency and diversity of multiclonal infections due to technical sensitivity and specificity. Next-generation sequencing techniques provide a novel opportunity to study complexity of...
Topics
- Adult
- Age Factors
- Ethiopia
- Genetic Variation
- Geography
- High-Throughput Nucleotide Sequencing
- Humans
- Kenya
- Malaria, Falciparum
- Malaria, Vivax
- Male