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Article

Molecular approaches to determine the multiplicity of Plasmodium infections.

Malaria journal - 23 Apr 2018

Zhong Daibin, Koepfli Cristian, Cui Liwang, Yan Guiyun

Abstract excerpt

Multiplicity of infection (MOI), also termed complexity of infection (COI), is defined as the number of genetically distinct parasite strains co-infecting a single host, which is an important indicator of malaria epidemiology. PCR-based genotyping often underestimates MOI. Next generation sequencing technologies provide much more accurate and genome-wide characterization of polyclonal infections. However,...

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Identifiers

PMID: 29685152
DOI: 10.1186/s12936-018-2322-5
PMCID: PMC5914063

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