Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysis.

doi:10.1016/j.lanmic.2024.07.004

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Article

Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysis.

The Lancet. Microbe - 1 Dec 2024

Miotto Olivo, Amambua-Ngwa Alfred, Amenga-Etego Lucas N, Abdel Hamid Muzamil M, Adam Ishag, Aninagyei Enoch, Apinjoh Tobias, Awandare Gordon A, Bejon Philip, Bertin Gwladys I, Bouyou-Akotet Marielle, Claessens Antoine, Conway David J, D'Alessandro Umberto, Diakite Mahamadou, Djimdé Abdoulaye, Dondorp Arjen M, Duffy Patrick, Fairhurst Rick M, Fanello Caterina I, Ghansah Anita, Ishengoma Deus S, Lawniczak Mara, Maïga-Ascofaré Oumou, Auburn Sarah, Rosanas-Urgell Anna, Wasakul Varanya, White Nina F D, Harrott Alexandria, Almagro-Garcia Jacob, Pearson Richard D, Goncalves Sonia, Ariani Cristina, Bozdech Zbynek, Hamilton William L, Simpson Victoria, Kwiatkowski Dominic P

Abstract excerpt

BACKGROUND: The population structure of the malaria parasite Plasmodium falciparum can reveal underlying adaptive evolutionary processes. Selective pressures to maintain complex genetic backgrounds can encourage inbreeding, producing distinct parasite clusters identifiable by population structure analyses. METHODS: We analysed population structure in 3783 P falciparum genomes from 21 countries across Africa,...

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PMID: 39522520
DOI: 10.1016/j.lanmic.2024.07.004
PMCID: PMC11628469

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