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Lipid nanoparticle-mediated delivery of mRNA for IL-21 achieves clearance of hepatitis B virus in mouse models

2023-03-17

Abstract excerpt

Chronic hepatitis B virus (HBV) infection causes hepatitis, liver cirrhosis and hepatocellular carcinoma. Covalently closed circular DNA (cccDNA) is the transcription template for HBV RNAs and not affected by current treatment options. Effective therapeutics with ability to remove cccDNA need to be developed. Previously, we established an HBV persistence mouse model via hydrodynamic injection of a clinical isolate...

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Literature Corpus work
9c5d225e-5158-53eb-be83-b782e8d40d73
DOI
10.22541/au.167904019.99394146/v1
Open publication

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Lipid nanoparticle-mediated delivery of mRNA for IL-21 achieves clearance of hepatitis B virus in mouse modelsDOI 10.22541/au.167904019.99394146/v1
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