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Article

Case-control analysis of LRRK2 protective variants in Essential Tremor.

Scientific reports - 28 Mar 2018

Ng Adeline S L, Ng Ebonne Y L, Tan Yi Jayne, Prakash Kumar M, Au Wing Lok, Tan Louis C S, Tan Eng-King

Abstract excerpt

Co-existence of Parkinson's disease (PD) and essential tremor (ET) may reflect overlapping pathophysiology underlying both conditions. Furthermore, PD patients with leucine-rich repeat kinase-2 (LRRK2) mutations may present with ET-like features, suggesting the possibility of common genetic underpinnings. Two common LRRK2 variants, R1398H and N551K, have been shown to be protective in multiple PD cohorts. We...

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Identifiers

PMID: 29593234
DOI: 10.1038/s41598-018-23711-w
PMCID: PMC5871891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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