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Article

Ras GAP-related and C-terminal domain-dependent localization and tumorigenic activities of IQGAP1 in melanoma cells.

PloS one - 1 Jan 2017

Reimer Michael, Denby Elisabeth, Zustiak Silviya P, Schober Joseph M

Abstract excerpt

IQGAP1 interacts with a number of binding partners through a calponin homology domain (CHD), a WW motif, IQ repeats, a Ras GAP-related domain (GRD), and a conserved C-terminal (CT) domain. Among various biological and cellular functions, IQGAP1 is known to play a role in actin cytoskeleton dynamics during membrane ruffling and lamellipodium protrusion. In addition, phosphorylation near the CT domain is thought to...

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Share to Actin Cytoskeleton
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Melanoma, Experimental

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Source

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Identifiers

PMID: 29240845
DOI: 10.1371/journal.pone.0189589
PMCID: PMC5730206

Genes

IQGAP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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