Article
IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.
Nature medicine - 1 May 2013
Jameson Katherine L, Mazur Pawel K, Zehnder Ashley M, Zhang Jiajing, Zarnegar Brian, Sage Julien, Khavari Paul A
Abstract excerpt
Upregulation of the ERK1 and ERK2 (ERK1/2) MAP kinase (MAPK) cascade occurs in >30% of cancers, often through mutational activation of receptor tyrosine kinases or other upstream genes, including KRAS and BRAF. Efforts to target endogenous MAPKs are challenged by the fact that these kinases are r...
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