Article

The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase

2022-09-25

Abstract excerpt

IQGAP1 is a multi-domain cancer-associated protein that serves as a scaffold protein for multiple signaling pathways. Numerous binding partners have been found for the calponin homology, IQ and GAP-related domains in IQGAP1. Identification of a binding partner for its WW domain has proven elusive, however, even though a cell-penetrating peptide derived from this domain has marked anti-tumor activity. Here, using...

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Identifiers and source

Literature Corpus work: d18a94d3-dd87-54b2-baa6-21044319264c
DOI: 10.1101/2022.09.24.509339

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