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Article

The lincRNA MIRAT binds to IQGAP1 and modulates the MAPK pathway in NRAS mutant melanoma.

Scientific reports - 19 Jul 2018

Sanlorenzo Martina, Vujic Igor, Esteve-Puig Rosaura, Lai Kevin, Vujic Marin, Lin Kevin, Posch Christian, Dimon Michelle, Moy Adrian, Zekhtser Mitchell, Johnston Katia, Gho Deborah, Ho Wilson, Gajjala Abhinay, Oses Prieto Juan, Burlingame Alma, Daud Adil, Rappersberger Klemens, Ortiz-Urda Susana

Abstract excerpt

Despite major advances in targeted melanoma therapies, drug resistance limits their efficacy. Long noncoding RNAs (lncRNAs) are transcriptome elements that do not encode proteins but are important regulatory molecules. LncRNAs have been implicated in cancer development and response to different therapeutics and are thus potential treatment targets; however, the majority of their functions and molecular...

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Share to GTP Phosphohydrolases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30026510
DOI: 10.1038/s41598-018-27643-3
PMCID: PMC6053443

Genes

IQGAP1
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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