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Identifying novel therapeutic targets in cystic fibrosis through advanced single-cell transcriptomics analysis

8 Feb 2025

Abstract excerpt

Lung disease remains a leading cause of morbidity and mortality in individuals with cystic fibrosis (CF). Despite significant advances, the complex molecular mechanisms underlying CF-related airway pathology are not fully understood. Building upon previous single-cell transcriptomics studies in CF patients and healthy controls, this study employs enhanced analytical methodologies to deepen our understanding of...

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PMID: 39921941
DOI: 10.1016/j.compbiomed.2025.109748

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