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Article

Nanoparticle delivery of RNA-based therapeutics to alter the vocal fold tissue response to injury.

The Laryngoscope - 1 May 2018

Hiwatashi Nao, Kraja Iv, Benedict Peter A, Dion Gregory R, Bing Renjie, Rousseau Bernard, Amin Milan R, Nalband Danielle M, Kirshenbaum Kent, Branski Ryan C

Abstract excerpt

OBJECTIVES/HYPOTHESIS: Our laboratory and others hypothesized that Smad3 is a principle mediator of the fibrotic phenotype in the vocal folds (VFs), and we further posited that alteration of Smad3 expression through short interfering (si)RNA holds therapeutic promise, yet delivery remains challenging. To address this issue, we employed a novel synthetic oligomer, lipitoid, complexed with siRNA to improve...

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Identifiers

PMID: 29238989
DOI: 10.1002/lary.27047
PMCID: PMC5910268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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