Article
Polymorphisms in Rhesus Macaque Tetherin Are Associated with Differences in Acute Viremia in Simian Immunodeficiency Virus Δnef-Infected Animals.
Journal of virology - 15 Nov 2018
Janaka Sanath Kumar, Tavakoli-Tameh Aidin, Neidermyer William J, Serra-Moreno Ruth, Hoxie James A, Desrosiers Ronald C, Johnson R Paul, Lifson Jeffrey D, Wolinsky Steven M, Evans David T
Abstract excerpt
Tetherin (BST-2 or CD317) is an interferon-inducible transmembrane protein that inhibits virus release from infected cells. To determine the extent of sequence variation and the impact of polymorphisms in rhesus macaque tetherin on simian immunodeficiency virus (SIV) infection, tetherin alleles were sequenced from 146 rhesus macaques, including 68 animals infected with wild-type SIVmac239 and 47 animals infected...
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