Effects of mutations in phage restriction sites during escape from restriction-modification.

Abstract excerpt

Restriction-modification systems are widespread genetic elements that protect bacteria from bacteriophage infections by recognizing and cleaving heterologous DNA at short, well-defined sequences called restriction sites. Bioinformatic evidence shows that restriction sites are significantly underrepresented in bacteriophage genomes, presumably because bacteriophages with fewer restriction sites are more likely to...

Topics

• Bacterial Proteins
• Bacteriophage lambda
• DNA Restriction-Modification Enzymes
• Escherichia coli
• Mutation