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Article

Evolution of sequence specificity in a restriction endonuclease by a point mutation.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jul 2008

Saravanan Matheshwaran, Vasu Kommireddy, Nagaraja Valakunja

Abstract excerpt

Restriction endonucleases (REases) protect bacteria from invading foreign DNAs and are endowed with exquisite sequence specificity. REases have originated from the ancestral proteins and evolved new sequence specificities by genetic recombination, gene duplication, replication slippage, and trans...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18647833
DOI: 10.1073/pnas.0804974105
PMCID: PMC2492507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18647833-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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