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Article

Evolution of sequence specificity in a restriction endonuclease by a point mutation.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jul 2008

Saravanan Matheshwaran, Vasu Kommireddy, Nagaraja Valakunja

Abstract excerpt

Restriction endonucleases (REases) protect bacteria from invading foreign DNAs and are endowed with exquisite sequence specificity. REases have originated from the ancestral proteins and evolved new sequence specificities by genetic recombination, gene duplication, replication slippage, and transpositional events. They are also speculated to have evolved from nonspecific endonucleases, attaining a high degree of...

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Source

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Identifiers

PMID: 18647833
DOI: 10.1073/pnas.0804974105
PMCID: PMC2492507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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