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Article

Veratramine modulates AP-1-dependent gene transcription by directly binding to programmable DNA

1 Dec 2017

Abstract excerpt

Because the transcription factor activator protein-1 (AP-1) regulates a variety of protein-encoding genes, it is a participant in many cellular functions, including proliferation, transformation, epithelial mesenchymal transition (EMT), and apoptosis. Inhibitors targeting AP-1 have potential use in the treatment of cancer and other inflammatory diseases. Here, we identify veratramine as a potent natural modulator...

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PMID: 29237043
DOI: 10.1093/nar/gkx1241

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