Article

Compound signaling activates endogenous retroviruses by inducing enhancer and gene-neighborhood transcription

2018-03-19

Abstract excerpt

<h4>Summary</h4> Multiple sclerosis (MS) is a neuroinflammatory and autoimmune disease, in which various immune cell types and autoreactive T cells exert a pathogenic activity. This disease is also associated with increased transcription of several endogenous retroviruses (HERVs) normally kept in check by heterochromatin. Here, we have uncovered an organic pollutant dieldrin that activates several HERVs associate...

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Literature Corpus work: 78a35486-b038-5e5f-aefa-effa8622ed76
DOI: 10.1101/284695

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