Article
Regulated expression of the lncRNA TERRA and its impact on telomere biology.
Mechanisms of ageing and development - 1 Oct 2017
Oliva-Rico Diego, Herrera Luis A
Abstract excerpt
The telomere protects against genomic instability by minimizing the accelerated end resection of the genetic material, a phenomenon that results in severe chromosome instability that could favor the transformation of a cell by enabling the emergence of tumor-promoting mutations. Some mechanisms that avoid this fate, such as capping and loop formation, have been very well characterized; however, telomeric...
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