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Article

Epitope Mapping of SERCA2a Identifies an Antigenic Determinant That Induces Mainly Atrial Myocarditis in A/J Mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2018

Krishnan Bharathi, Massilamany Chandirasegaran, Basavalingappa Rakesh H, Gangaplara Arunakumar, Rajasekaran Rajkumar A, Afzal Muhammad Z, Khalilzad-Sharghi Vahid, Zhou You, Riethoven Jean-Jack, Nandi Shyam S, Mishra Paras K, Sobel Raymond A, Strande Jennifer L, Steffen David, Reddy Jay

Abstract excerpt

Sarcoplasmic/endoplasmic reticulum Ca2+ adenosine triphosphatase (SERCA)2a, a critical regulator of calcium homeostasis, is known to be decreased in heart failure. Patients with myocarditis or dilated cardiomyopathy develop autoantibodies to SERCA2a suggesting that they may have pathogenetic significance. In this report, we describe epitope mapping analysis of SERCA2a in A/J mice that leads us to make five...

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Identifiers

PMID: 29229678
DOI: 10.4049/jimmunol.1701090
PMCID: PMC5760440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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