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Article

Disruption of the mouse necdin gene results in early post-natal lethality.

Nature genetics - 1 Oct 1999

Gérard M, Hernandez L, Wevrick R, Stewart C L

Abstract excerpt

Prader-Willi syndrome (PWS) is a neurobehavioural disorder characterized by neonatal respiratory depression, hypotonia and failure to thrive in infancy, followed by hyperphagia and obesity among other symptoms. PWS is caused by the loss of one or more paternally expressed genes on chromosome 15q11-q13, which can be due to gene deletions, maternal uniparental disomy or mutations disrupting the imprinting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10508517
DOI: 10.1038/13828

Genes

SNRPN
NDN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Disruption of the mouse necdin gene results in early post-natal lethality.PMID 10508517Read ↗

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