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Article

Induced pluripotent stem cells (iPSC) created from skin fibroblasts of patients with Prader-Willi syndrome (PWS) retain the molecular signature of PWS.

Stem cell research - 1 Nov 2016

Burnett Lisa C, LeDuc Charles A, Sulsona Carlos R, Paull Daniel, Eddiry Sanaa, Levy Brynn, Salles Jean Pierre, Tauber Maithe, Driscoll Daniel J, Egli Dieter, Leibel Rudolph L

Abstract excerpt

Prader-Willi syndrome (PWS) is a syndromic obesity caused by loss of paternal gene expression in an imprinted interval on 15q11.2-q13. Induced pluripotent stem cells were generated from skin cells of three large deletion PWS patients and one unique microdeletion PWS patient. We found that genes within the PWS region, including SNRPN and NDN, showed persistence of DNA methylation after iPSC reprogramming and...

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Identifiers

PMID: 27789403
DOI: 10.1016/j.scr.2016.08.008
PMCID: PMC8202351

Genes

NDN
SNRPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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