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Article

Activation of the imprinted Prader-Willi syndrome locus by CRISPR-based epigenome editing

1 Feb 2025

Abstract excerpt

Epigenome editing with DNA-targeting technologies such as CRISPR-dCas9 can be used to dissect gene regulatory mechanisms and potentially treat associated disorders. For example, Prader-Willi syndrome (PWS) results from loss of paternally expressed imprinted genes on chromosome 15q11.2-q13.3, although the maternal allele is intact but epigenetically silenced. Using CRISPR repression and activation screens in human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39947136
DOI: 10.1016/j.xgen.2025.100770

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