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COPS5 and LASP1 synergistically interact to downregulate 14‐3‐3σ expression and promote colorectal cancer progression via activating PI3K/AKT pathway

11 Dec 2017

Abstract excerpt

Overexpression of LIM and SH3 protein 1 (LASP1) is required for colorectal cancer (CRC) development and progression. Here, C-Jun activation domain-binding protein-1 (Jab1), also known as COP9 signalosome subunit 5 (COPS5), was verified as a new LASP1-interacting protein through yeast two-hybrid assay. The role of COPS5 in LASP1-mediated CRC progression remains unknown. GST pull-down assay indicated that the SH3...

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Identifiers

PMID: 29226323
DOI: 10.1002/ijc.31206

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