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Article

LIM kinase 1 interacts with myosin-9 and alpha-actinin-4 and promotes colorectal cancer progression.

British journal of cancer - 8 Aug 2017

Liao Qing, Li Rui, Zhou Rui, Pan Zhihua, Xu Lijun, Ding Yanqing, Zhao Liang

Abstract excerpt

BACKGROUND: LIM kinase 1 (LIMK1) is a key regulator of the cytoskeletal organisation involved in cell proliferation and migration. Even though LIMK1 is frequently dysregulated in epithelial cancers, the role and mechanisms of LIMK1 in colorectal cancer (CRC) remains unclear. METHODS: Immunohistochemical analysis was performed to examine the expression and clinical significance of LIMK1 in CRC samples. Loss- and...

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Source

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Identifiers

PMID: 28664914
DOI: 10.1038/bjc.2017.193
PMCID: PMC5558682

Genes

LIMK1
ACTN4
MYH9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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