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LASP1 promotes nasopharyngeal carcinoma progression through negatively regulation of the tumor suppressor PTEN

12 Mar 2018

Abstract excerpt

LIM and SH3 protein 1 (LASP1) enhances tumor growth and metastasis in various cancers, but its role in nasopharyngeal carcinoma (NPC) remains unclear. Herein, we investigated the role of LASP1 in NPC and explored the underlying mechanisms in NPC. Clinically, overexpression of LASP1 is associated with tumor metastasis and poor prognosis of NPC patients. Gain-of-function and loss-of-function assays showed that...

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PMID: 29531214
DOI: 10.1038/s41419-018-0443-y

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