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Article

Prognostic significance of localized p27Kip1 and potential role of Jab1/CSN5 in pancreatic cancer

1 Feb 2004

Abstract excerpt

p27Kip1 belongs to the family of small polypeptides collectively termed cyclin-dependent kinase inhibitors, which negatively regulate the cell cycle progression. In various human cancers, the reduced p27Kip1 expression correlates well with poor prognosis. Recently, Jab1/CSN5, the fifth component of the COP9 signalosome complex, was found to specifically translocate p27Kip1 from the nucleus to the cytoplasm, and...

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PMID: 14719054
DOI: 10.3892/or.11.2.277

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