Article
Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis.
Cellular & molecular immunology - 1 Oct 2018
Consuegra-Fernández Marta, Julià Marc, Martínez-Florensa Mario, Aranda Fernando, Català Cristina, Armiger-Borràs Noelia, Arias María-Teresa, Santiago Francisca, Guilabert Antonio, Esteve Anna, Muñoz Carlos, Ferrándiz Carlos, Carrascosa José-Manuel, Pedrosa Edurne, Romaní Jorge, Alsina Mercè, Mascaró-Galy José-Manuel, Lozano Francisco
Abstract excerpt
Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for the treatment of certain autoimmune disorders, including psoriasis. Here, we present novel...
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