Article
The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2011
Kofler David M, Severson Christopher A, Mousissian Narine, De Jager Philip L, Hafler David A
Abstract excerpt
Genome-wide association studies have revealed a large number of genetic associations with autoimmune diseases. Despite this progress, the mechanisms underlying the contribution of allelic variants to the onset of immune-related diseases remain mostly unknown. Our recent meta-analysis of genome-wide association studies of multiple sclerosis (MS) identified a new susceptibility locus tagged by a single nucleotide...
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