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Article

Polymorphisms in the CD6-ALCAM axis may modulate psoriasis risk and outcomes.

Human immunology - 1 May 2024

Wagner Marta, Sobczyński Maciej, Wiśniewski Andrzej, Matusiak Łukasz, Kuśnierczyk Piotr, Jasek Monika

Abstract excerpt

The fact that CD6, along with its ligand - ALCAM, plays a role in regulating T cell activation makes the genes encoding these molecules promising candidates for research in T cell-mediated diseases such as psoriasis vulgaris (PsV). Our study aimed to determine whether CD6 (rs17824933C>G, rs11230563C>T and rs12360861G>A) and ALCAM (rs6437585C>T, rs11559013G>A) polymorphisms may affect psoriasis susceptibility and...

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Identifiers

PMID: 38580538
DOI: 10.1016/j.humimm.2024.110797

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