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Article

Activation of CD8 T cells accelerates anti-PD-1 antibody-induced psoriasis-like dermatitis through IL-6.

Communications biology - 15 Oct 2020

Tanaka Ryota, Ichimura Yuki, Kubota Noriko, Saito Akimasa, Nakamura Yoshiyuki, Ishitsuka Yosuke, Watanabe Rei, Fujisawa Yasuhiro, Kanzaki Mirei, Mizuno Seiya, Takahashi Satoru, Fujimoto Manabu, Okiyama Naoko

Abstract excerpt

Use of immune checkpoint inhibitors that target programmed cell death-1 (PD-1) can lead to various autoimmune-related adverse events (irAEs) including psoriasis-like dermatitis. Our observations on human samples indicated enhanced epidermal infiltration of CD8 T cells, and the pathogenesis of which appears to be dependent on IL-6 in the PD-1 signal blockade-induced psoriasis-like dermatitis. By using a murine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33060784
DOI: 10.1038/s42003-020-01308-2
PMCID: PMC7567105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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