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Article

[Effects of NPM1 gene expression on acute myeloid leukemia cell lines and its mechanism].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 14 Nov 2017

Qiu S W, Wan Y L, Wang M, Wang J X

Abstract excerpt

Objective: To investigate the impact and mechanism of NPM1 gene expression on acute myeloid leukemia (AML) cell lines. Methods: Human AML cell line U937 and HL-60 cells were transfected with NPM1 plasmid to establish stable clones, and the high NPM1 protein expression (NPM1(hi)) clones were screened by Western blot. The cell proliferation was assayed by methylthiazolyl tetrazolium bromide (MTT) , cell cycle and...

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Share to Apoptosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 29224316
DOI: 10.3760/cma.j.issn.0253-2727.2017.11.008
PMCID: PMC7342777

Genes

NPM1
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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