Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Study of the effects and mechanism of all-trans retinoic acid on leukemic cell line U937 cells with NPM1 mutation].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 14 Oct 2017

Qiu S W, Wan Y L, Jia Y J, Rao Q, Wang M, Wang J X

Abstract excerpt

Objective: To investigate the effect and mechanism of all-trans retinoic acid (ATRA) on leukemic cell line U937 cells with NPM1 mutation. Methods: Human acute myeloid leukemia cell line U937 was explored, NPM1 mutated (A type) plasmids were transfected into U937 to form stable clones A1 and A2, which were identified by Western blot and Co-immunoprecipitation. The cell proliferation was measured by methylthiazolyl...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NPM1 gene

Share to Mutation

Share to Nuclear Proteins

Share to Nucleophosmin

Share to Tretinoin

Share to U937 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 29166739
DOI: 10.3760/cma.j.issn.0253-2727.2017.10.008
PMCID: PMC7364968

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Study of the effects and mechanism of all-trans retinoic acid on leukemic cell line U937 cells with NPM1 mutation].PMID 29166739Read ↗

[Effects of NPM1 gene expression on acute myeloid leukemia cell lines and its mechanism].Semantic proximity Read ↗

The success and the challenge of all-trans retinoic acid in the treatment of cancerSemantic proximity Read ↗

Unlocking the potential of retinoic acid in anticancer therapySemantic proximity Read ↗

Realgar-induced apoptosis and differentiation in all-trans retinoic acid (ATRA)-sensitive NB4 and ATRA-resistant MR2 cellsSemantic proximity Read ↗

Extramedullary relapse after all-trans retinoic acid treatment in acute promyelocytic leukemia – the occurrence of retinoic acid syndrome is a risk factorSemantic proximity Read ↗

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells.Semantic proximity Read ↗

Synergistic effect of all‑trans retinoic acid in combination with protein kinase C 412 in FMS-like tyrosine kinase 3-mutated acute myeloid leukemia cells.Semantic proximity Read ↗

Synergistic targeted therapy for acute promyelocytic leukaemia: a model of translational research in human cancerSemantic proximity Read ↗

Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.Semantic proximity Read ↗

[Effect of endoplasmic reticulum stress induced by all-trans retinoic acid on apoptosis of FLT3-ITD mutated leukemia cells by activating autophagy in FLT3-ITD mutated protein].Semantic proximity Read ↗

[Significance of Retinol-Binding Protein Expression in Patients with Acute Myeloid Leukemia].Semantic proximity Read ↗

Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.