Article
Aiolos regulates B cell activation and maturation to effector state.
Immunity - 1 Oct 1998
Wang J H, Avitahl N, Cariappa A, Friedrich C, Ikeda T, Renold A, Andrikopoulos K, Liang L, Pillai S, Morgan B A, Georgopoulos K
Abstract excerpt
Aiolos encodes a zinc finger DNA-binding protein that is highly expressed in mature B cells and is homologous to Ikaros. In the periphery of mice homozygous for an Aiolos-null mutation, B cells exhibit an activated cell surface phenotype and undergo augmented antigen receptor (BCR)-mediated in vi...
Topics
- Animals
- Autoantibodies
- B-Lymphocytes
- Base Sequence
- Cell Differentiation
- Cytokines
- DNA Primers
- DNA-Binding Proteins
- Hematopoietic Stem Cells
- Ikaros Transcription Factor
- Immunoglobulins
- In Vitro Techniques
- Lymphocyte Activation
- Lymphoma, B-Cell
- Macromolecular Substances