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Autophagy controls mesenchymal stem cell properties and senescence during bone aging

6 Dec 2017

Abstract excerpt

Bone marrow-derived mesenchymal stem cells (BMMSCs) exhibit degenerative changes, including imbalanced differentiation and reduced proliferation during aging, that contribute to age-related bone loss. We demonstrate here that autophagy is significantly reduced in aged BMMSCs compared with young BMMSCs. The autophagy inhibitor 3-methyladenine (3-MA) could turn young BMMSCs into a relatively aged state by reducing...

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PMID: 29210174
DOI: 10.1111/acel.12709

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