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Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues

18 Jun 2015

Abstract excerpt

The aging population and the incidence of aging-related diseases such as osteoporosis are on the rise. Aging at the tissue and organ levels usually involves tissue stem cells. Human and animal model studies indicate that aging affects two aspects of mesenchymal stem cell (MSC): a decrease in the bone marrow MSC pool and biased differentiation into adipocyte at the cost of osteoblast, which underlie the etiology...

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PMID: 26088863
DOI: 10.1177/1535370215591828

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